Author

F. J. Canada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Ariza· 1 shared A. J. Rodero· 1 shared A. Prunotto· 1 shared B. Gerber· 1 shared D. Perez-Sala· 1 shared E. T. Sumrall· 1 shared F. J. Sanchez-Gomez· 1 shared I. Kalograiaki· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Ariza

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2 papers

Recent·Most cited

Molecular basis for recognition of Listeria cell wall teichoic acid by the pseudo-symmetric SH3b-like repeats of a bacteriophage endolysin

Y. Shen, I. Kalograiaki, A. Prunotto, M. Dunne, S. Boulos, N. M. I. Taylor, E. T. Sumrall, M. R. Eugster, R. Martin, A. J. Rodero, B. Gerber, P. G. Leiman, M. F. Menendez, M. D. Peraro, F. J. Canada, L. J. Martin

The paper describes the atomic-level interaction between a bacteriophage endolysin's CBD500 domain and Listeria cell wall teichoic acid, identifying key epitopes and binding mechanisms.

bioRxiv · Jun 5, 2020Biophysics

Amoxicillin inactivation by thiol-catalyzed cyclization reduces protein haptenation and antibacterial potency

M. A. Pajares, T. Zimmerman, F. J. Sanchez-Gomez, A. Ariza, M. J. Torres, M. Blanca, F. J. Canada, M. I. Montanez, D. Perez-Sala

This study shows that thiol-catalyzed cyclization of amoxicillin reduces protein haptenation and antibacterial potency by converting it to diketopiperazine.

bioRxiv · May 26, 2019Pharmacology & Toxicology