Y. Shen

Explainable Multimodal Prognostic Modeling Uncovers New Clinically Relevant Pathological Features in a Multi-Institutional Pancreatic Neuroendocrine Tumor Cohort

This paper develops a multimodal prognostic model for pancreatic neuroendocrine tumors using clinicopathologic data and histology images, finding that stromal features are as prognostic as tumor cells.

Behavior decoding delineates seizure microfeatures and associated sudden death risks in mice

AI-aided behavior decoding identifies seizure microfeatures and SUDEP risks in mice using machine learning tools.

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

The paper identifies early high-amplitude rhythmic spikes in the hippocampus of mice after traumatic brain injury as predictive of post-traumatic epilepsy.

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

This study identifies PA28γ's role in promoting oral squamous cell carcinoma progression by enhancing mitochondrial function through interaction with C1QBP.

Strawberry COP9 signalosome FvCSN5A regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H2O2 homeostasis

This study identifies FvCSN5A as a regulator of polyamine and H2O2 homeostasis in strawberries by controlling FvPAO5 degradation, affecting plant development and fruit ripening.

MAGE-A4-Responsive Plasma Cells Promote Non-Small Cell Lung Cancer

The paper shows MAGE-A4 promotes NSCLC by recruiting IgA+ plasma cells, reducing tumor burden and enhancing T cell activity.

Cooperativity among clustered κB sites within promoters and enhancers dictates transcriptional specificity of NF-κB RelA along with specific cofactors

Targeting SEZ6L2 in Colon Cancer: Efficacy of Bexarotene and Implications for Survival

This study investigates SEZ6L2's role in colon cancer, showing its overexpression as a prognostic biomarker and Bexarotene's ability to downregulate it, with context-dependent therapeutic effects.

Perfringolysin O pore-forming complexes are predominantly integral multiples of six subunits

The paper investigates the structural composition of Perfringolysin O (PFO) complexes, finding that they are predominantly hexameric and built from hexameric sub-complexes.

Inactivation of PRMT1 inhibits cardiac fibrosis via transcriptional regulation and perturbation of FBL activity in fibroblast-to-myofibroblast transition

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function

This study identifies msiCAT-tailing of mitochondrial proteins as a mechanism promoting glioblastoma growth by enhancing mitochondrial function and reducing apoptosis.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

Mechanical regulation of cellular energy metabolism in cancer microenvironments

The paper develops a model linking matrix stiffness and ligand density to cellular bioenergetics in cancer cells, showing how mechanical forces influence metabolic pathways and contractility.

Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification

This study shows osteoblast-derived matrix vesicles (Ost-MVs) contribute to atherosclerotic calcification by being released into circulation and transported to plaques, where they exacerbate calcification through the Ras-Raf-ERK pathway.

Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

Multi-species numerical validation of an efficient algorithm for auditory brainstem response hearing threshold estimation

The paper validates an adaptive algorithm for estimating ABR hearing thresholds across multiple species, showing it matches human estimates within 10 dB while reducing measurement time by 3-5 times.

Dnmt3a mutations limit normal and autoreactive Tfh differentiation

This study shows that Dnmt3a mutations impair Tfh differentiation, contributing to autoimmune joint inflammation and reduced immune responses.

Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae

This study isolates human monoclonal antibodies against hypervirulent, pandrug-resistant Klebsiella pneumoniae and identifies capsule-specific antibodies as protective against bloodstream infection.

Pre-existing Immunity to Influenza Aids Ferrets in Developing Stronger and Broader Vaccine-induced Antibody Responses

This study shows that pre-existing immunity in ferrets enhances vaccine-induced antibody responses, reducing the need for booster shots and broadening protection against homologous and heterologous influenza strains.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system for Saccharolobus islandicus

The paper designs mutated pRN1 plasmid backbones to evade CRISPR immunity in Saccharolobus islandicus, enabling stable plasmid vectors and a dual plasmid system for genetic studies.

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

New insights into functional divergence and adaptive evolution of uncultured bacteria in anammox community by complete genome-centric analysis

The paper uses long-read sequencing to obtain complete metagenome-assembled genomes of anammox bacteria, revealing functional divergence and adaptive evolution through horizontal gene transfer and mobile genetic elements.

Biogenic phosphonate utilization by globally distributed diatom Thalassiosira

This study shows that the diatom Thalassiosira pseudonana can use biogenic phosphonates as a phosphorus source, affecting its elemental stoichiometry and growth under phosphorus starvation.

A monochromatically excitable green-red dual-fluorophore fusion incorporating a new large Stokes shift fluorescent protein

The paper introduces a new fluorescent protein, LSSmApple, and uses it to create a genetically encoded calcium sensor for yeast imaging.