Vimentin cysteine 328 modifications finely tune network organization and influence actin remodeling under oxidative and electrophilic stress
P. Gonzalez-Jimenez, S. Duarte, A. E. Martinez…·D. Perez-Sala
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5 papers
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P. Gonzalez-Jimenez, S. Duarte, A. E. Martinez…·D. Perez-Sala
V. Lalioti, S. Gonzalez-Sanz, I. Lois-Bermejo…·D. Perez-Sala
This study investigates the surface localization of vimentin and ACE2 in response to SARS-CoV-2 Spike proteins using immunofluorescence, revealing cell-type-specific colocalization patterns.
A. Monico, J. Guzman-Caldentey, M. A. Pajares…·D. Perez-Sala
This study investigates vimentin's interaction with zinc ions and oxidative modifications using crosslinking assays and molecular dynamics simulations, revealing zinc's role in stabilizing Cys328 and preventing alkylation.
M. A. Pajares, T. Zimmerman, F. J. Sanchez-Gomez…·D. Perez-Sala
This study shows that thiol-catalyzed cyclization of amoxicillin reduces protein haptenation and antibacterial potency by converting it to diketopiperazine.
S. Duarte, A. Viedma-Poyatos, E. Navarro-Carrasco…·D. Perez-Sala
This study shows vimentin filaments redistribute to the mitotic cortex during cell division, with their tail domain essential for proper mitosis, and disruption leads to mitotic errors.