In situ structure determination of virus capsids imaged within cell nuclei by correlative light and cryo-electron tomography.
S. Vijayakrishnan, M. McElwee, C. Loney, F. J. Rixon, D. Bhella
The paper determines the structure of herpesvirus capsids within cell nuclei using cryo-ET and sub-tomogram averaging, revealing the presence of the tegument complex before nuclear egress.
bioRxiv · Feb 6, 2020Biophysics