TREM2 limits necrotic core formation during atherogenesis by controlling macrophage survival and efferocytosis
M. Piollet, F. Porsch, G. Rizzo, F. Kapser, D. J. Schulz, M. G. Kiss, K. Schlepckow, E. Morenas-Rodriguez, M. O. Sen, J. Gropper, M. Roesch, L. Goederle, A. Hladik, S. Knapp, M. Colonna, , C. Cochain
This study shows TREM2 deficiency increases necrotic core formation in atherosclerosis by impairing macrophage efferocytosis and survival.
bioRxiv · May 15, 2023 · PreprintImmunology