M. Colonna

Species- and strain-effects in interferon, innate immunity, and barrier transcriptional response of microbiome interactions of 3D respiratory epithelial cultures

The paper examines how different microbes affect host immune and barrier responses in respiratory epithelial cultures, finding that interferon variability is not linked to microbial diversity or other innate pathways.

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATION

This study shows that CB2R on microglia drives neuroinflammation in GVHD by promoting T cell activation and neuronal death, and that targeting CB2R reduces inflammation without worsening systemic GVHD.

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions

The paper identifies a common neuroprotective response of microglia at retinal atrophy sites in mice and humans, mediated by galectin-3 and Trem2 interactions.

TREM2 limits necrotic core formation during atherogenesis by controlling macrophage survival and efferocytosis

This study shows TREM2 deficiency increases necrotic core formation in atherosclerosis by impairing macrophage efferocytosis and survival.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

The Transcription Factor Bach2 Negatively Regulates Natural Killer Cell Maturation and Function

This study shows Bach2 negatively regulates NK cell maturation and function by correlating with TCF1 and opposing effector molecule and cell cycle gene expression.

IL-34 deficiency impairs FOXP3+ Treg function and increases susceptibility to autoimmunity

This study shows IL-34 deficiency impairs FOXP3+ Treg function, leading to autoimmunity and increased susceptibility to colitis and graft rejection.

Surveillance of Shiga toxin-producing Escherichia coli associated bloody diarrhea in Argentina

The paper investigates STEC-associated bloody diarrhea and progression to HUS in children in Argentina, finding 4.1% STEC-positive cases and 13.8% progressing to HUS.

A novel redox-active switch in Fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

This study identifies redox-sensitive cysteines in Fructosamine-3-kinases (FN3Ks) that regulate their activity and dimerization through disulfide bonds, revealing a novel redox regulatory mechanism in the protein kinase superfamily.

Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming

This study identifies shared and unique features between peripheral nerve macrophages and CNS microglia, showing PNS macrophages express genes associated with microglial activation.

Toxoplasma gondii infection drives conversion of NK Cells into ILC1s

This study shows Toxoplasma gondii infection converts NK cells into ILC1-like cells that persist and circulate independently of infection.

High affinity interactions and signal transduction between Aβ oligomers and TREM2

This study investigates the high-affinity interaction between TREM2 and Aβ oligomers, showing that AD-associated TREM2 variants have reduced signaling and internalization capacity.