Author

M. Dumoulin

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Vanderplasschen· 1 shared Bart De StrooperiD· 1 shared C. Lamarre· 1 shared Casey ChertavianiD· 1 shared D. Blum· 1 shared D. Thiry· 1 shared Disha ShahiD· 1 shared F. Cawez· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. Vanderplasschen

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3 papers

Recent·Most cited

TRPML1 loss drives lysosomal calcium failure and astrocyte dysfunction across Alzheimer's Disease progression

Disha Shah, Perlina Desai, Casey Chertavian, Millie J. Thackray, M. Dumoulin, Verity F. T. Mitchener, Molly Strom, Bart De Strooper, I. Lorena Arancibia‐Cárcamo

This study identifies TRPML1 loss as a cause of lysosomal calcium failure and astrocyte dysfunction in Alzheimer's Disease, showing that restoring TRPML1 can prevent disease progression.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Development of nanobodies as theranostic agents against CMY-2-like class C β-lactamases

F. Cawez, P. S. Mercuri, F. M. Yanez, R. Maalouf, M. Vandevenne, F. Kerff, V. Guerin, J. G. Mainil, D. Thiry, M. Salmon, A. Vanderplasschen, P. Lafaye, G. Ayme, P. Bogaerts, M. Dumoulin, M. Galleni

This study identifies VHH nanobodies that inhibit CMY-2 class C β-lactamases and develops an ELISA for detecting these enzymes in resistant bacteria.

bioRxiv · Jul 1, 2022 · PreprintBiochemistry

A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

M. Tautou, S. Eddarkaoui, F. Descamps, P.-E. Larchanche, M. Dumoulin, C. Lamarre, D. Blum, L. Buee, P. Melnyk, N. Sergeant

The paper identifies two β-secretase modulators, MAGS02-14 and PEL24-199, and shows that PEL24-199 reduces Tau pathology and improves short-term memory in a mouse model of neurofibrillary degeneration.

Frontiers in Pharmacology · Jun 29, 2021Peer-reviewedPharmacology & Toxicology