F. Krach

RNA splicing modulator induces peripheral neuropathy with increased neurofilament light chain levels via p53 signaling

This paper shows that the RNA splicing modulator branaplam causes peripheral neuropathy by activating p53 signaling, leading to increased neurofilament light chain levels in motor neurons.

Proximity labeling reveals an extensive steady-state stress granule interactome and insights to neurodegeneration

The paper identifies over 100 novel stress granule proteins using proximity labeling and shows they form a dense interaction network, with implications for neurodegeneration.