W. Jin

Synchronization of Circadian Clock Gene Expression in Arabidopsis and Hyaloperonospora arabidopsidis and its Impact on Host-Pathogen Interactions

This study identifies circadian clock genes in the oomycete pathogen Hpa and shows their synchronization with host Arabidopsis clock genes, impacting virulence.

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets.

The paper identifies epigenetic regulation of key pathways and novel druggable targets in glioblastoma by comparing chromatin remodelling in neoplastic and neural stem cells.

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

SIX4 Controls STING Expression Enhancing anti-PD-1 Efficacy

This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.

Dynamics, signals and influencing factors of CD4 T cell activation revealed by single cell RNA-seq

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Mechanically active integrins direct cytotoxic secretion at the immune synapse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

Mathematical model of tumour spheroid experiments with real-time cell cycle imaging

This paper develops a mathematical model to interpret FUCCI-labelled tumour spheroid growth experiments, capturing cell cycle dynamics and drug responses.

Neonicotinoids stimulate H2-limited methane emission in Periplaneta americana through the regulation of gut bacterium community

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives

This study evaluates the antiviral activity of heparin and enoxaparin derivatives against SARS-CoV-2 by testing their ability to neutralize pseudotyped virus particles.

Senile plaques in Alzheimer's disease arise from Aβ and Cathepsin D-enriched amyloidogenic mixtures out of intravascular hemolysis and Charcot-Bouchard aneurysm-related vascular degeneration

This study identifies that senile plaques in Alzheimer's disease originate from Aβ and Cathepsin D-enriched amyloid mixtures formed through intravascular hemolysis and vascular degeneration.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

Identifying density-dependent interactions in collective cell behaviour

The paper develops an individual-based model to study density-dependent cell behavior in scratch assays, finding that motility depends on cell density but proliferation does not.

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

TrkB induced metastatic potential of cancer by suppression of BMP mediated tumor inhibitory activity

The paper investigates how TrkB signaling suppresses BMP-mediated tumor inhibitory activity by disrupting BMP receptor complex formation and downregulating RUNX3 and KEAP1.

New mathematical modelling tools for co-culture experiments: when do we need to explicitly account for signalling molecules?

The paper develops a discrete model for co-culture cell migration and derives a reduced model under steady-state assumptions, comparing it to a full model to determine when simplification is valid.

Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing

This study shows that centrioles affect the capacity but not the specificity of cytotoxic T cell killing by impacting granule biogenesis and actin remodeling, not granule polarization.

Metabolic wastes are extracellularly disposed by excretosomes, nanotubes and exophers in mouse HT22 cells through an autophagic vesicle clustering mechanism

This study identifies excretosomes and exophers as mechanisms for metabolic waste disposal in HT22 cells, showing their role in stress response and neurodegenerative disease pathology.

Revisiting the Fisher-KPP equation to interpret the spreading-extinction dichotomy

This paper revisits the Fisher-KPP model to provide new insights into the spreading-extinction dichotomy by analyzing its travelling wave solutions and their relationship to the Fisher-Stefan model.

Extension of the in vivo haploid induction system from diploid maize to hexaploid wheat

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.

Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells

Cytotoxic T cells use actin-rich protrusions at immunological synapses to enhance perforin and granzyme-mediated killing of target cells.

Stochastic models of cell invasion with fluorescent cell cycle indicators

The paper develops a stochastic model of cell invasion in scratch assays using fluorescent cell cycle indicators and validates it with experimental data.

Extended logistic growth model for heterogeneous populations

This paper extends the logistic growth model to account for heterogeneity in cell proliferation rates, showing that ignoring this variability can lead to misleading results in proliferation assays.

Cryptic phylogeographic history sheds light on the generation of species diversity in sky-island mountains

This study uses phylogeographic analysis of the long-tailed mole to reveal how complex topography and climate stability in Chinese sky islands drive genetic divergence and species diversification.

A computational modelling framework to quantify the effects of passaging cell lines

This study uses computational modeling to show that passage number affects cell proliferation rates and scratch assay closure rates, highlighting the need to report passage numbers for reproducibility.

Proximity labeling reveals an extensive steady-state stress granule interactome and insights to neurodegeneration

The paper identifies over 100 novel stress granule proteins using proximity labeling and shows they form a dense interaction network, with implications for neurodegeneration.