Activation and substrate specificity of the human P4-ATPase ATP8B1
T. Dieudonne, F. Kummerer, M. Juknaviciute Laursen, C. Stock, R. Kock Flygaard, S. Khalid, G. Lenoir, J. A. Lyons, K. Lindorff-Larsen, P. Nissen
This study presents cryo-EM structures and functional analysis of the human ATP8B1-CDC50A complex, revealing its mechanism of action, substrate specificity, and regulation by phosphoinositides.
bioRxiv · Apr 12, 2023Biochemistry