Author

J. A. Lyons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

P. Nissen· 4 shared C. Stock· 2 shared G. Lenoir· 2 shared K. Lindorff-Larsen· 2 shared T. Dieudonne· 2 shared A. V. Almeida· 1 shared B. L. de Groot· 1 shared C. Jaxel· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

P. Nissen

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Author profile →

5 papers

Recent·Most cited

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

T. A. Gadeberg, M. H. Joergensen, H. G. Olesen, J. Lorentzen, S. L. Harwood, A. V. Almeida, M. U. Fruergaard, R. K. Jensen, P. Kanis, H. Pedersen, E. Tranchant, S. V. Petersen, I. B. Thoegersen, J. A. Lyons, J. J. Enghild, G. R. R. Andersen

This study uses cryo-EM to analyze the structural changes in C3 during hydrolysis, revealing a dynamic opening in the macroglobulin ring that allows domain translocation.

bioRxiv · Apr 15, 2024Biochemistry

Activation and substrate specificity of the human P4-ATPase ATP8B1

T. Dieudonne, F. Kummerer, M. Juknaviciute Laursen, C. Stock, R. Kock Flygaard, S. Khalid, G. Lenoir, J. A. Lyons, K. Lindorff-Larsen, P. Nissen

This study presents cryo-EM structures and functional analysis of the human ATP8B1-CDC50A complex, revealing its mechanism of action, substrate specificity, and regulation by phosphoinositides.

Nature Communications · Nov 18, 2023Peer-reviewedBiochemistry

Variations of a theme - crystal forms of the amino acid transporter MhsT

C. M. T. Neumann, D. Focht, S. Trampari, J. A. Lyons, P. Nissen

The paper reports on the crystallization of MhsT with different substrates, revealing varied crystal packing arrangements and challenges in structure determination due to crystal imperfections.

bioRxiv · May 3, 2022Biochemistry

Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

T. Dieudonne, S. A. Herrera, M. J. Laursen, M. Lejeune, C. Stock, K. Slimani, C. Jaxel, J. A. Lyons, C. Montigny, T. G. Pomorski, P. Nissen, G. Lenoir

This study investigates the autoinhibition and regulation of ATP8B1, a lipid flippase, through functional studies and cryo-EM structure analysis, revealing the role of phosphoinositides and terminal segments in its activity.

bioRxiv · Nov 3, 2021Biochemistry

Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase

Y. Wang, J. A. Lyons, M. Timcenko, F. Kümmerer, B. L. de Groot, P. Nissen, V. Gapsys, K. Lindorff-Larsen

The paper uses molecular dynamics simulations to study phospholipid transport and specificity in a flippase, revealing a preference for phosphatidylserine and insights into substrate selectivity mechanisms.

bioRxiv · Jun 24, 2020 · PreprintBiophysics