Extracellular Matrix Stiffness Promotes Vascular Smooth Muscle Cell Calcification by Reducing The Levels of Nuclear Actin Monomers
M. C. McNeill, F. L. Chee, R. Ebrhimighaei, G. B. Sala Newby, A. C. Newby, T. Hathway, A. S. Annaiah, S. Joseph, M. Carrabba, M. Bond
This paper shows that increased extracellular matrix stiffness promotes vascular smooth muscle cell calcification by reducing nuclear actin monomer levels, which represses YAP-mediated osteogenic differentiation.
bioRxiv · Jun 18, 2023 · PreprintCell Biology