S. Joseph

MAPK14/p38α Shapes the Molecular Landscape of Endometrial Cancer and promotes Tumorigenic Characteristics

This study identifies MAPK14/p38α as critical for HGEC spheroid growth, shaping its transcriptomic, proteomic, and metabolomic landscapes and promoting tumorigenic properties.

History of recurrent short and long-term coral bleaching events in Indian coral reefs: a systematic review of contrasting bleaching patterns, lessons learned, and future directions

This study reviews 23 years of coral bleaching events in Indian reefs to identify species susceptibility patterns and highlight the need for repeated surveys to accurately assess bleaching impacts.

Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

This study examines how the loss of IP3R calcium signaling affects transcriptional regulation and identifies three key adaptations in IP3R TKO cells.

Identification of a short, single site matriglycan that maintains neuromuscular function in the mouse

The paper identifies a shorter matriglycan on dystroglycan that maintains neuromuscular function in adult mice and protects skeletal muscle from damage.

The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities.

This study characterizes DDR and CTA transcriptional landscapes in endometrial cancer subtypes, identifies aggressive subtypes, and reveals therapeutic vulnerabilities.

Schisandrin B suppresses colon cancer growth by inducing cell cycle arrest and apoptosis via the CHOP signalling pathway

This study identifies Schisandrin B's mechanism of action in colon cancer, showing it induces cell cycle arrest and apoptosis via the CHOP signalling pathway.

Extracellular Matrix Stiffness Promotes Vascular Smooth Muscle Cell Calcification by Reducing The Levels of Nuclear Actin Monomers

This paper shows that increased extracellular matrix stiffness promotes vascular smooth muscle cell calcification by reducing nuclear actin monomer levels, which represses YAP-mediated osteogenic differentiation.

LINC00261 expression reduces mutation accumulation while conferring resistance to cisplatin and altering the tumor-immune microenvironment in lung adenocarcinoma

This study identifies LINC00261 as a gene that reduces mutation accumulation, confers cisplatin resistance, and alters the tumor-immune microenvironment in lung adenocarcinoma.

Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

This study shows that the N-terminal domain of dystroglycan is required for LARGE1 to extend matriglycan to its full length, preventing muscular dystrophy.

Insulin receptor turnover in fasting is dependent on beta-dystroglycan deglycosylation

The paper shows that insulin receptor turnover during fasting depends on beta-dystroglycan deglycosylation mediated by lysosomal enzymes and NAGLU-induced transcriptional activation.

Structure and mechanism of LARGE1 matriglycan polymerase

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

Transcriptomic changes in the pituitary of female mice with androgen excess through dihydrotestosterone (DHT) treatment

This study identifies 583 differentially expressed genes in the pituitary of female mice treated with dihydrotestosterone, revealing androgen-responsive pathways and transcriptional changes linked to androgen excess.

A Simple Method to Dual Site-Specifically Label a Protein Using Tryptophan Auxotrophic Escherichia coli

The paper presents a method to dual site-specifically label proteins using tryptophan auxotrophic E. coli and 5-hydroxytryptophan, demonstrated with E. coli release factor 1.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

The paper investigates how a three-dimensional pre-mRNA structural scaffold influences spliceosomal component recruitment beyond traditional splice signals.

Influenza A virus NS1 protein binds as a dimer to the RNA-free PABP1 but not to the PABP1-Poly(A) RNA Complex

This study shows that IAV NS1 binds as a dimer to RNA-free PABP1 but not to PABP1-poly(A) RNA complex, suggesting it may stimulate translation initiation by interacting with the 5-end of mRNA.

The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through its RGG and C-terminal domains

This study investigates how FMRP inhibits translation by examining its effects on m7G-cap-dependent and cap-independent translation and identifies the RGG and C-terminal domains as key for translation inhibition.

A Simple Procedure for Bacterial Expression and Purification of the Fragile X Protein Family

This paper describes a method for expressing and purifying full-length human FMRP, FXR1P, and FXR2P from E. coli with high yields and purity.

Nanoparticle Tracking Analysis: A powerful tool for characterizing magnetosome preparations

This paper uses Nanoparticle Tracking Analysis (NTA) to characterize magnetosome size distribution and concentration changes under ultrasonication and SDS treatment.

POMK Regulates Dystroglycan Function via LARGE-mediated Elongation of Matriglycan

This study shows that POMK phosphorylates core M3 to enable LARGE to elongate matriglycan on dystroglycan, preventing muscular dystrophy.

Quality of eyeglass prescriptions from a low-cost wavefront autorefractor evaluated in rural India: results of a 708-participant field study

This study evaluates a low-cost wavefront autorefractor's ability to provide accurate eyeglass prescriptions in rural India, finding comparable visual acuity and patient preference to subjective refraction.

Comparative Genomics Of Apomictic Root-Knot Nematodes: Hybridization, Ploidy, And Dynamic Genome Change

This study sequenced 19 genomes of Root-Knot Nematodes to investigate hybridization, ploidy, and genome dynamics in the Meloidogyne incognita group.