CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia
A. ALLOUCH, L. VOISIN, Y. ZHANG, R. SYED, Y. LECLUSE, J. CALVO, D. Selimoglu-Buet, S. DE BOTTON, F. LOUACHE, F. PFLUMIO, E. SOLARY, j.-l. PERFETTINI
This study shows that overexpressing CDKN1A in macrophages enhances their ability to phagocytose leukemic cells, leading to pro-inflammatory reprogramming and improved survival in mouse models.
bioRxiv · Jan 18, 2022Immunology