J. Calvo

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

High CD44 expression identifies rare chemoresistant leukemic cells endowed with enhanced E-Selectin binding in T-ALL

The paper identifies a chemoresistant leukemic stem cell population in T-ALL with high CD44 expression and enhanced E-selectin binding, associated with poor prognosis and relapse.

CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

This study shows that overexpressing CDKN1A in macrophages enhances their ability to phagocytose leukemic cells, leading to pro-inflammatory reprogramming and improved survival in mouse models.

Replication gaps are a cancer vulnerability counteracted by translesion synthesis

The paper identifies that oncogene expression creates replication gaps, which are suppressed by translesion synthesis (TLS), and shows that inhibiting TLS reduces cancer cell fitness.

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

Replication gaps underlie BRCA-deficiency and therapy response

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.