Author

F. Luca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Organism:yeast· 1

Frequent Co-Authors

R. Pique-Regi· 2 shared A. Findley· 1 shared C. Boye· 1 shared C. E. McCarthy-Leo· 1 shared C. Kalita· 1 shared G. S. Brush· 1 shared K. E. Lohmueller· 1 shared L. Barreiro· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

R. Pique-Regi

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2 papers

Recent·Most cited

Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2

C. E. McCarthy-Leo, G. S. Brush, R. Pique-Regi, F. Luca, M. A. Tainsky, R. L. Finley

The paper functionally tests most CHEK2 SNVs using a yeast complementation assay, finding 770 damaging and 2,417 tolerated variants, aiding in pathogenicity prediction.

bioRxiv · Dec 22, 2023 · PreprintCancer Biology

A signature of Neanderthal introgression on molecular mechanisms of environmental responses

A. Findley, X. Zhang, C. Boye, Y.-L. Lin, C. Kalita, L. Barreiro, K. E. Lohmueller, R. Pique-Regi, F. Luca

The paper identifies Neanderthal introgression variants that influence gene expression in response to environmental perturbations and validates their regulatory function.

bioRxiv · Mar 15, 2021Evolutionary Biology