HIV-1 provirus excised by single CRISPR/Cas9 RNA guide persists in host cell and may be reactivated
M. Lai, E. Maori, P. Quaranta, G. Matteoli, F. Maggi, M. Sgarbanti, S. Crucitta, S. Paci, O. Turriziani, G. Freer, J. L. Heeney, G. Antonelli, M. Pistello
This study shows that HIV-1 provirus excised by CRISPR/Cas9 can persist and be reactivated, highlighting the need for additional antiviral therapy to fully eradicate infection.
bioRxiv · Nov 16, 2020 · PreprintMicrobiology