M. Lai

N-acylethanolamine acid amidase inhibition reduces SARS-CoV-2 infection in Human Precision cut-lung slices and downregulates NF-kappaB signalling.

This study shows that inhibiting NAAA reduces SARS-CoV-2 replication in human lung tissue and suppresses NF-kappaB signaling.

Diversity and ecological potentials of viral assemblages from the seamount sediments of the Northwest Pacific Ocean

The paper analyzes viral diversity in seamount sediments, identifying 78,069 vOTUs and 16 vAMGs, suggesting ecological roles in biogeochemical cycles.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

N-acylethanolamine acid amide hydrolase is a novel target for drugs against SARS-CoV-2 and Zika virus

This paper shows that inhibiting NAAA reduces SARS-CoV-2 and ZIKV replication and inflammation in cell lines and human PBMCs.

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

This study compares metabolic and transcriptomic profiles of glioblastoma in patient tumors and orthotopic xenografts in mice to identify invasion-related molecular signatures.

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

The paper uses multi-scale fluorescence microscopy to study SARS-CoV-2 variant entry into Vero E6 cells, finding B.1.1.7 enters faster than its ancestor due to the N501Y mutation.

Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition

The paper determines the native structure of the RhopH complex from malaria parasites using cryo-EM and mass spectrometry, revealing insights into its assembly and trafficking.

HIV-1 provirus excised by single CRISPR/Cas9 RNA guide persists in host cell and may be reactivated

This study shows that HIV-1 provirus excised by CRISPR/Cas9 can persist and be reactivated, highlighting the need for additional antiviral therapy to fully eradicate infection.