Author

G. Freer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

M. Lai· 3 shared M. Pistello· 3 shared P. Quaranta· 3 shared g. lottini· 2 shared P. G. Spezia· 2 shared A. De Carli· 1 shared A. Diaspro· 1 shared A. Mengozzi· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

M. Lai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

N-acylethanolamine acid amide hydrolase is a novel target for drugs against SARS-CoV-2 and Zika virus

M. Lai, V. La Rocca, R. Amato, E. Iacono, c. filipponi, E. Catelli, L. Bogani, R. Fonnesu, g. lottini, A. De Carli, A. Mengozzi, S. Masi, P. Quaranta, P. G. Spezia, G. Freer, , M. Pistello

This paper shows that inhibiting NAAA reduces SARS-CoV-2 and ZIKV replication and inflammation in cell lines and human PBMCs.

bioRxiv · Feb 8, 2022 · PreprintMicrobiology

A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

B. Storti, P. Quaranta, C. Di Primio, N. Clementi, N. Mancini, E. Criscuolo, P. G. Spezia, V. Carnicelli, G. Lottini, E. Paolini, G. Freer, M. Lai, M. Costa, F. Beltram, A. Diaspro, , R. Bizzarri

The paper uses multi-scale fluorescence microscopy to study SARS-CoV-2 variant entry into Vero E6 cells, finding B.1.1.7 enters faster than its ancestor due to the N501Y mutation.

bioRxiv · Mar 31, 2021Biophysics

HIV-1 provirus excised by single CRISPR/Cas9 RNA guide persists in host cell and may be reactivated

M. Lai, E. Maori, P. Quaranta, G. Matteoli, F. Maggi, M. Sgarbanti, S. Crucitta, S. Paci, O. Turriziani, G. Freer, J. L. Heeney, G. Antonelli, M. Pistello

This study shows that HIV-1 provirus excised by CRISPR/Cas9 can persist and be reactivated, highlighting the need for additional antiviral therapy to fully eradicate infection.

bioRxiv · Nov 16, 2020 · PreprintMicrobiology