Author

F. Michel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. Pellegrini· 2 shared A. Hlinak· 1 shared A. Le Tortorec· 1 shared A. Muluneh· 1 shared A. Rolland· 1 shared B. Höcker· 1 shared B. Sadeghi· 1 shared C. M. Holicki· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

S. Pellegrini

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Retracing the evolution of a modern periplasmic binding protein

F. Michel, S. Romero-Romero, B. Höcker

This study reconstructs a single-lobed progenitor of a periplasmic binding protein by deconstructing a modern RBP, showing that recombination of its lobes restores function and structure.

bioRxiv · May 30, 2023Biochemistry

Reconstruction of the molecular evolution of Usutu virus in Germany: Insights into virus emersion and circulation

F. Bergmann, C. M. Holicki, F. Michel, S. Bock, N. Scuda, G. Priemer, S. Kenklies, T. Siempelkamp, J. Skuballa, C. Sauerwald, L. Herms, A. Muluneh, M. Peters, A. Hlinak, M. H. Groschup, , U. Ziegler

This study reconstructs the molecular evolution of Usutu virus in Germany, identifying its introduction and genetic evolution within the country.

bioRxiv · Feb 28, 2023 · PreprintEvolutionary Biology

Human USP18 is regulated by miRNAs via the 3'UTR, a sequence duplicated in lincRNA genes residing in chr22q11.21

E. Rubino, M. Cruciani, N. Tchitchek, A. Le Tortorec, A. Rolland, O. Veli, L. Vallet, G. Gaggi, F. Michel, N. Dejucq-Rainsford, S. Pellegrini

The paper identifies miRNAs that regulate USP18 via its 3'UTR and discovers duplicated 3'UTR sequences in lincRNAs on chr22q11.21, suggesting a regulatory network for baseline USP18 levels.

bioRxiv · Oct 7, 2020Immunology

Treating Influenza and SARS-CoV-2 via mRNA-encoded Cas13a

E. L. Blanchard, D. Vanover, S. S. Bawage, P. M. Tiwari, L. Rotolo, J. Beyersdorf, H. E. Peck, N. C. Bruno, R. Hincapie, M. G. Finn, F. Michel, E. R. Lafontaine, R. J. Hogan, C. Zurla, P. J. Santangelo

This study uses mRNA-encoded Cas13a to target and reduce influenza and SARS-CoV-2 RNA in vitro and in a mouse model, showing potential for therapeutic applications.

bioRxiv · Apr 24, 2020 · PreprintBioengineering

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

Z. Li, M. Rotival, E. Patin, F. Michel, S. Pellegrini

This study shows two TYK2 variants affect exon splicing and mildly enhance TYK2 expression, potentially contributing to autoimmune diseases.

bioRxiv · Nov 4, 2019Immunology