Author

E. Patin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 5 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant effect prediction· 2 Assay:whole-exome sequencing· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

L. Quintana-Murci· 5 shared G. Kerner· 2 shared G. Laval· 2 shared A. Froment· 1 shared A. Guerin· 1 shared A. Kousathanas· 1 shared A. L. Byrd· 1 shared B. Bigio· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersEvolutionary Biology

L. Quintana-Murci

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Author profile →

6 papers

Recent·Most cited

Deep estimation of the intensity and timing of selection from ancient genomes

G. Laval, E. Patin, L. Quintana-Murci, G. Kerner

This paper uses CNNs to estimate selection intensity and timing from ancient genomes, improving upon ABC methods and confirming historical selection events in Europe.

bioRxiv · Jul 27, 2023 · PreprintEvolutionary Biology

Stability and dynamics of the human gut microbiome and its association with systemic immune traits

A. L. Byrd, M. Liu, K. E. Fujimura, S. Lyalina, D. R. Nagarkar, B. Charbit, E. Patin, O. J. Harrison, L. Quintana-Murci, D. Duffy, M. L. Albert, The Milieu Interieur Consortium

The paper analyzes gut microbiome data from 946 donors to show age-related changes in bacterial profiles and links them to immune traits, supporting personalized microbial therapeutics.

bioRxiv · Jan 17, 2020Microbiology

A genome-wide Approximate Bayesian Computation approach suggests only limited numbers of soft sweeps in humans over the last 100,000 years

G. Laval, E. Patin, P. Boutillier, L. Quintana-Murci

bioRxiv · Dec 22, 2019 · PreprintEvolutionary Biology

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

Z. Li, M. Rotival, E. Patin, F. Michel, S. Pellegrini

This study shows two TYK2 variants affect exon splicing and mildly enhance TYK2 expression, potentially contributing to autoimmune diseases.

bioRxiv · Nov 4, 2019Immunology

IRF4 haploinsufficiency in a family with Whipples disease

A. Guerin, G. Kerner, N. Marr, J. G. Markle, F. Fenollar, N. Wong, S. Boughorbel, D. T. Avery, C. Ma, S. Bougarn, M. Bouaziz, V. Beziat, E. Della Mina, T. Lazarovt, L. Worley, , J.-L. Casanova

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.

bioRxiv · Oct 3, 2017Immunology

The demographic history and mutational load of African hunter-gatherers and farmers

M. Lopez, A. Kousathanas, H. Quach, C. Harmant, P. Mouguiama-Daouda, J.-M. Hombert, A. Froment, G. H. Perry, L. B. Barreiro, P. Verdu, E. Patin, L. Quintana-Murci

This study analyzes the demographic history and mutational load of African hunter-gatherers and farmers using exome sequencing data, finding similar mutation loads despite differing demographic histories.

bioRxiv · May 3, 2017Evolutionary Biology