Direct observation of Hsp90-induced compaction in a protein chain
A. Mashaghi, F. Moayed, E. J. Koers, G. Kramer, M. P. Mayer, S. J. Tans
This study uses optical tweezers to show Hsp90 induces local contractions in unfolded protein chains, leading to global compaction and suppression of misfolding and aggregation.
bioRxiv · Aug 8, 2021Biophysics