A two-level, dynamic fitness landscape of hepatitis C virus revealed by self-organized haplotype maps
S. Delgado, C. Perales, C. Garcia-Crespo, M. E. Soria, I. Gallego, A. I. de Avila, B. Martinez-Gonzalez, L. Vazquez-Sirvent, C. Lopez-Galindez, F. Moran, E. Domingo
This study constructs a dynamic two-layer fitness landscape of HCV using self-organized haplotype maps from deep sequencing data during adaptation in cell culture.
bioRxiv · Apr 22, 2021 · PreprintMicrobiology