I. Gallego

The paper determines the cryo-EM structure of a triplet polymerase ribozyme and maps its functional landscape using mutation analysis.

This study shows that guanosine inhibits HCV replication by altering intracellular nucleotide pools, leading to increased indels and reduced viral infectivity.

The paper analyzes SARS-CoV-2 mutant spectra from diagnostic samples and finds higher point mutation complexity in isolates from patients with mild disease compared to moderate or severe disease.

This study constructs a dynamic two-layer fitness landscape of HCV using self-organized haplotype maps from deep sequencing data during adaptation in cell culture.

The paper identifies six amino acid substitutions associated with HCV treatment failure that are not resistance-associated substitutions but are highly represented in viral quasispecies.

The paper examines conservation patterns in HCV mutant spectra, consensus sequences, and data banks, finding mismatches that challenge assumptions about sequence conservation for vaccine design.