Author

C. Perales

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:statistical model· 3 Research Focus:variant calling· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. I. de Avila· 5 shared E. Domingo· 5 shared I. Gallego· 5 shared M. E. Soria· 5 shared B. Martinez-Gonzalez· 4 shared C. Garcia-Crespo· 4 shared L. Vazquez-Sirvent· 4 shared J. Gomez· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

A. I. de Avila

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools

R. Sabariegos, A. M. Ortega-Prieto, L. Diaz-Martinez, A. Grande-Perez, I. Gallego, A. I. de Avila, M. E. Soria, P. Gastaminza, E. Domingo, C. Perales, A. Mas

This study shows that guanosine inhibits HCV replication by altering intracellular nucleotide pools, leading to increased indels and reduced viral infectivity.

PLOS Pathogens · Jan 27, 2022Peer-reviewedMicrobiology

SARS-CoV-2 Point Mutation and Deletion Spectra, and Their Association with Different Disease Outcome

B. Martinez-Gonzalez, M. E. Soria, L. Vazquez-Sirvent, C. Ferrer-Orta, R. Lobo-Vega, P. Minguez, L. De la Fuente, C. Llorens, B. Soriano, R. Ramos-Ruiz, M. Corton, R. Lopez-Rodriguez, C. Garcia-Crespo, I. Gallego, A. I. de Avila, , C. Perales

The paper analyzes SARS-CoV-2 mutant spectra from diagnostic samples and finds higher point mutation complexity in isolates from patients with mild disease compared to moderate or severe disease.

bioRxiv · Jan 10, 2022Microbiology

A two-level, dynamic fitness landscape of hepatitis C virus revealed by self-organized haplotype maps

S. Delgado, C. Perales, C. Garcia-Crespo, M. E. Soria, I. Gallego, A. I. de Avila, B. Martinez-Gonzalez, L. Vazquez-Sirvent, C. Lopez-Galindez, F. Moran, E. Domingo

This study constructs a dynamic two-layer fitness landscape of HCV using self-organized haplotype maps from deep sequencing data during adaptation in cell culture.

bioRxiv · Apr 22, 2021 · PreprintMicrobiology

Amino acid substitutions associated with treatment failure of hepatitis C virus infection

M. E. Soria, C. Garcia-Crespo, B. Martinez-Gonzalez, L. Vazquez-Sirvent, R. Lobo-Vega, A. I. de Avila, I. Gallego, Q. Chen, D. Garcia-Cehic, M. Llorens-Revull, C. Briones, J. Gomez, C. Ferrer-Orta, N. Verdaguer, J. Gregori, , C. Perales

The paper identifies six amino acid substitutions associated with HCV treatment failure that are not resistance-associated substitutions but are highly represented in viral quasispecies.

Journal of Clinical Microbiology · Nov 18, 2020Peer-reviewedMicrobiology

Dissimilar conservation pattern in hepatitis C virus mutant spectra, consensus sequences, and data banks

C. Garcia-Crespo, M. E. Soria, I. Gallego, A. I. De Avila, B. Martinez-Gonzalez, L. Vazquez-Sirvent, J. Gomez, C. Briones, J. Gregori, J. Quer, C. Perales, E. Domingo

The paper examines conservation patterns in HCV mutant spectra, consensus sequences, and data banks, finding mismatches that challenge assumptions about sequence conservation for vaccine design.

Journal of Clinical Medicine · Oct 27, 2020Peer-reviewedMicrobiology