The 5-LOX/COX-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis
F. Nakashima, J. A. Gimenez-Bastida, P. B. Luis, S. H. Presley, R. E. Boer, M. Chiusa, T. Shibata, G. A. Sulikowski, A. Pozzi, C. Schneider
This study identifies HKE2, a cross-over metabolite of 5-LOX and COX-2, as a pro-angiogenic agent that activates VEGFR2 and promotes angiogenesis in vitro and in vivo.
bioRxiv · May 13, 2022 · PreprintPharmacology & Toxicology