Pharmacology & ToxicologybioRxivPreprint
The 5-LOX/COX-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis
F. Nakashima, J. A. Gimenez-Bastida, P. B. Luis…·C. Schneider
This study identifies HKE2, a cross-over metabolite of 5-LOX and COX-2, as a pro-angiogenic agent that activates VEGFR2 and promotes angiogenesis in vitro and in vivo.
DOI 10.1101/2022.05.13.491890