Field cancerization impacts tumor development, T-cell exhaustion and clinical outcomes in bladder cancer
T. Strandgaard, I. Nordentoft, K. Birkenkamp-Demtroder, L. Salminen, F. Prip, J. Rasmussen, T. G. Andreasen, S. V. Lindskrog, E. Christensen, P. Lamy, M. Knudsen, T. Steiniche, J. B. Jensen, L. Dyrskjot
This study shows that field cancerization in bladder cancer is linked to worse outcomes, higher mutational burden, and T-cell exhaustion, with urinary tumor DNA levels reflecting disease status.
bioRxiv · Feb 20, 2023 · PreprintCancer Biology