Author

M. Knudsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. B. Jensen· 3 shared L. Dyrskjot· 3 shared P. Lamy· 3 shared S. V. Lindskrog· 3 shared F. Prip· 2 shared I. Nordentoft· 2 shared S. S. Schmokel· 2 shared T. Strandgaard· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

J. B. Jensen

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Author profile →

3 papers

Recent·Most cited

Field cancerization impacts tumor development, T-cell exhaustion and clinical outcomes in bladder cancer

T. Strandgaard, I. Nordentoft, K. Birkenkamp-Demtroder, L. Salminen, F. Prip, J. Rasmussen, T. G. Andreasen, S. V. Lindskrog, E. Christensen, P. Lamy, M. Knudsen, T. Steiniche, J. B. Jensen, L. Dyrskjot

This study shows that field cancerization in bladder cancer is linked to worse outcomes, higher mutational burden, and T-cell exhaustion, with urinary tumor DNA levels reflecting disease status.

bioRxiv · Feb 20, 2023 · PreprintCancer Biology

Single nucleus and spatially resolved intra-tumor subtype heterogeneity in bladder cancer

S. V. Lindskrog, S. S. Schmokel, I. Nordentoft, P. Lamy, M. Knudsen, F. Prip, T. Strandgaard, J. B. Jensen, L. Dyrskjot

This study investigates intra-tumor subtype heterogeneity in bladder cancer using single nucleus RNA-sequencing and spatial transcriptomics, showing higher class 2a weight in bulk RNA-sequencing correlates with worse outcomes.

bioRxiv · Oct 27, 2022Cancer Biology

Improved Protocol for Single-Nucleus RNA-sequencing of Frozen Human Bladder Tumor Biopsies

S. S. Schmokel, I. K. Nordentoft, S. V. Lindskrog, P. Lamy, M. Knudsen, J. B. Jensen, L. Dyrskjot

This paper develops a protocol for snRNA-seq of frozen human bladder tumor biopsies, showing optimal conditions for nuclei isolation with minimal transcriptomic changes.

bioRxiv · Oct 14, 2022Cancer Biology