An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism
J. A. Lees, J. M. Dias, F. Rajamohan, J.-P. Fortin, R. O'Connor, J. X. Kong, E. Hughes, E. L. Fisher, J. B. Tuttle, G. Lovett, B. L. Kormos, R. J. Unwalla, L. Zhang, A.-M. Dechert Schmidt, D. Zhou, , S. Han
The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.
bioRxiv · May 1, 2023 · PreprintBiophysics