DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)
T. Simon, P. Riemer, K. Detjen, A. Di Domenico, F. Bormann, A. Menne, S. Khouja, N. Monje, L. H. Childs, D. Lenze, U. Leser, A. Jarosch, F. Rossner, M. Morkel, N. Bluethgen, , C. Sers
The paper uses DNA methylation analysis to distinguish high-grade PanNECs from other PanNETs, revealing an exocrine cell of origin for PanNECs.
bioRxiv · Jun 12, 2020Cancer Biology