Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
T.-T. Wei, E. Blanc, S. Peidli, P. Bischoff, A. Trinks, D. Horst, C. Sers, N. Bluthgen, D. Beule, M. Morkel, B. Obermayer
The paper develops CCISM to distinguish cancer cells from normal epithelial cells in single-cell data, identifying a novel stem-like cell state in the colorectal cancer microenvironment.
bioRxiv · Feb 23, 2024Cancer Biology
A. Trinks, M. Milek, D. Beule, J. Kluge, S. Florian, C. Sers, D. Horst, M. Morkel, P. Bischoff
The paper compares single-cell RNA sequencing from fresh, cryopreserved, and FFPE lung cancer tissues, finding FFPE tissues can reliably detect clinically relevant features.
bioRxiv · Apr 25, 2023Pathology
T. Sell, C. Klotz, M. M. Fischer, R. Astaburuaga-Garciia, S. Krug, J. Drost, H. Clevers, M. Morkel, N. Bluthgen
This study shows oncogenic signalling in colorectal cancer is linked to cell differentiation states through a defined axis, with mutations affecting stemness and differentiation.
bioRxiv · Apr 7, 2022 · PreprintCancer Biology
P. Bischoff, A. Trinks, J. Wiederspahn, B. Obermayer, J. P. Pett, P. Jurmeister, A. Elsner, T. Dziodzio, J.-C. Rückert, J. Neudecker, C. Falk, D. Beule, C. Sers, M. Morkel, D. Horst, , N. Blüthgen
This study uses single-cell RNA sequencing to analyze lung carcinoid tumors, revealing their cellular composition, gene expression profiles, and potential therapeutic targets.
bioRxiv · Dec 7, 2021Cancer Biology
D. Niemeyer, S. Schroeder, K. Friedmann, F. Weege, J. Trimpert, A. Richter, S. Stenzel, J. Jansen, J. Emanuel, J. Kazmierski, F. Pott, L. M. Jeworowski, R. Olmer, M.-C. Jaboreck, B. Tenner, , C. Drosten
The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.
bioRxiv · Oct 20, 2021 · PreprintMicrobiology
P. Bischoff, A. Trinks, B. Obermayer, J. P. Pett, A. Lehmann, P. Jurmeister, A. Elsner, T. Dziodzio, J.-C. Rückert, J. Neudecker, C. Falk, D. Beule, C. Sers, M. Morkel, D. Horst, , F. Klauschen
The paper uses single-cell RNA sequencing to identify two distinct tumor microenvironmental patterns in lung adenocarcinoma, associated with different prognostic outcomes.
bioRxiv · Dec 11, 2020Cancer Biology
T. Simon, P. Riemer, K. Detjen, A. Di Domenico, F. Bormann, A. Menne, S. Khouja, N. Monje, L. H. Childs, D. Lenze, U. Leser, A. Jarosch, F. Rossner, M. Morkel, N. Bluethgen, , C. Sers
The paper uses DNA methylation analysis to distinguish high-grade PanNECs from other PanNETs, revealing an exocrine cell of origin for PanNECs.
bioRxiv · Jun 12, 2020Cancer Biology
F. Uhlitz, P. Bischoff, S. Peidli, A. Sieber, B. Obermayer, E. Blanc, A. Trinks, M. Luethen, Y. Ruchiy, T. Sell, S. Mamlouk, R. Arsie, T.-T. Wei, K. Klotz-Noack, R. Schwarz, , M. Morkel
The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.
bioRxiv · Jan 10, 2020Cancer Biology
R. Brandt, T. Sell, M. Luethen, F. Uhlitz, B. Klinger, P. Riemer, C. Giesecke, S. Schulze, I. A. El-Shimy, D. Kunkel, B. Fauler, T. Mielke, N. Mages, B. G. Herrmann, C. Sers, , M. Morkel
The paper investigates how oncogenic KRAS and BRAF differentially activate ERK in colon cancer and intestinal epithelium, revealing cell type-specific effects and novel regulatory mechanisms.
bioRxiv · Feb 14, 2019Cell Biology
N. Rohwer, S. Jumpertz, M. Erdem, A. Egners, K. T. Warzecha, A. Fragoulis, A. A. Kuehl, R. Kramann, S. Neuss, I. Rudolph, T. Endermann, C. Zasada, I. Apostolova, M. Gerling, S. Kempa, , T. Cramer
This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.
bioRxiv · Feb 28, 2018Cancer Biology