Author

T. Simon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Di Domenico· 1 shared A. Jarosch· 1 shared A. Menne· 1 shared A. Perren· 1 shared A. R. Damato· 1 shared C. Sers· 1 shared D. A. Golombek· 1 shared D. Capper· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Di Domenico

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2 papers

Recent·Most cited

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

M. F. Gonzalez-Aponte, A. R. Damato, L. L. Trebucq, T. Simon, S. P. Cardenas-Garcia, K. Cho, G. J. Patti, D. A. Golombek, J. J. Chiesa, E. D. Herzog

This study shows that TMZ efficacy in glioblastoma varies with time-of-day due to circadian rhythms in MGMT expression and promoter methylation, with optimal treatment at the peak of Bmal1 expression.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)

T. Simon, P. Riemer, K. Detjen, A. Di Domenico, F. Bormann, A. Menne, S. Khouja, N. Monje, L. H. Childs, D. Lenze, U. Leser, A. Jarosch, F. Rossner, M. Morkel, N. Bluethgen, , C. Sers

The paper uses DNA methylation analysis to distinguish high-grade PanNECs from other PanNETs, revealing an exocrine cell of origin for PanNECs.

bioRxiv · Jun 12, 2020Cancer Biology