The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner
D. J. Hamelin, D. Fournelle, J.-C. Grenier, J. Schockaert, K. Kovalchik, P. Kubiniok, F. Mostefai, J. D. Duquette, F. Saab, I. Sirois, M. Smith, S. Pattijn, H. Soudeyns, H. Decaluwe, J. Hussin, E. Caron
This study analyzes SARS-CoV-2 mutations to show how they diversify T cell targets in an HLA supertype-dependent manner, leading to epitope loss in B7 supertype carriers.
bioRxiv · Jun 3, 2021Immunology