Author

I. Sirois

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Caron· 3 shared K. Kovalchik· 2 shared P. Kubiniok· 2 shared A. Caballe· 1 shared A. Garcia-Garijo· 1 shared A. Gros· 1 shared A. Marcu· 1 shared C. Stephan-Otto Attolini· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

E. Caron

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Induction of senescence renders cancer cells highly immunogenic

I. Marin, O. Boix, A. Garcia-Garijo, i. Sirois, A. Caballe, E. Zarzuela, I. Ruano, C. Stephan-Otto Attolini, N. Prats, J. A. Lopez-Dominguez, M. Kovatcheva, E. Garralda, J. Munoz, E. Caron, M. Abad, , M. Serrano

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

bioRxiv · Jun 5, 2022 · PreprintCancer Biology

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner

D. J. Hamelin, D. Fournelle, J.-C. Grenier, J. Schockaert, K. Kovalchik, P. Kubiniok, F. Mostefai, J. D. Duquette, F. Saab, I. Sirois, M. Smith, S. Pattijn, H. Soudeyns, H. Decaluwe, J. Hussin, E. Caron

This study analyzes SARS-CoV-2 mutations to show how they diversify T cell targets in an HLA supertype-dependent manner, leading to epitope loss in B7 supertype carriers.

bioRxiv · Jun 3, 2021Immunology

Global Analysis of the Mammalian MHC class I Immunopeptidome at the Organism-Wide Scale

P. Kubiniok, A. Marcu, L. Bichmann, L. Kuchenbecker, H. Schuster, D. Hamelin, J. Despault, K. Kovalchik, L. Wessling, O. Kohlbacher, S. Stevanovic, R. Hans-Georg, M. C. Neidert, I. Sirois, E. Caron

The paper analyzes the MHC class I immunopeptidome across human and mouse tissues, identifying tissue-specific and -independent peptide properties and hyperconserved protein sources.

bioRxiv · Sep 28, 2020 · PreprintImmunology