Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.
M. E. Candela, D. J. P. Allsop, R. N. Carter, F. Semple, F. Kilanowski, S. Webb, D. Taggart, H. J. W. Mullan, B. J. McHugh, D. H. Dockrell, D. J. Davidson, J. E. Allen, S. J. Jenkins, N. M. Morton, J. R. Dorin
This paper shows HBD3 limits macrophage classical activation and promotes alternative activation via IL-4R, enabling a repair-conducive state.
bioRxiv · May 6, 2021 · PreprintImmunology