S. Webb

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Effects of TP63 Mutations on Keratinocyte Adhesion and Migration

This study investigates how TP63 mutations affect keratinocyte adhesion and migration in AEC patients, finding reduced expression of adhesion components and impaired migration.

Histone divergence in Trypanosoma brucei results in unique alterations to nucleosome structure

This study characterizes the structure of nucleosome core particles from Trypanosoma brucei, revealing unique histone alterations that affect DNA and protein interactions.

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

Systemic influences of mammary cancer on monocytes in mice

This study shows that mammary cancer in mice increases circulating and splenic monocytes without altering their ratios or half-lives, but changes their transcriptome, particularly in the bone marrow and blood, with differences from human breast cancer.

Classical macrophage polarisation is limited by human β-defensin 3 via an autocrine IL-4 dependent process.

This paper shows HBD3 limits macrophage classical activation and promotes alternative activation via IL-4R, enabling a repair-conducive state.

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy

This study shows that Tmem120a knockout in mice disrupts fat genome organisation, leading to lipodystrophy and metabolic defects, with similarities to human FPLD2.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

A cell atlas of human thymic development defines T cell repertoire formation

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic

The paper uses mathematical modeling and experimental analysis to show MeCP2 creates 'slow sites' in gene bodies, affecting RNA polymerase II traffic and gene expression.