Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform.
W. Dalleywater, A. V. Predeus, B. Cakir, P. Mazin, J. Vadakekolathu, S. Rutella, M. L. Meakin, A. A. Ritchie, S. Montazid, S. Cuevas Ocana, N. Holmes, V. Wright, F. Seng, A. Bills, D. Sculthorpe, , M. Ilyas
This paper develops a co-differentiation platform using human iPSCs to generate transplantable colonic tissue that mimics native mucosa and responds to biological signals.
bioRxiv · Dec 8, 2023 · PreprintCell Biology