RAS and PP2A activities converge on epigenetic gene regulation
A. Aakula, M. Sharma, F. Tabaro, H. Honkanen, M. Schapira, C. Arrowsmith, M. Nykter, J. Westermarck
This study identifies epigenetic gene regulation as a convergence point for RAS hyperactivity and PP2A inhibition in cancer, showing their co-regulation of key chromatin modifiers and oncogenic transcription.
bioRxiv · May 11, 2022Cancer Biology