M. Sharma

Characterization and classification of fine-resolution soil profile for precision agriculture using random forest and self-organizing map

This study uses random forest and self-organizing map models to classify fine-resolution soil profiles for precision agriculture, finding random forest achieves over 85% prediction accuracy.

Machine Learning Approaches in Label-Free Small Extracellular Vesicles Analysis with Surface-Enhanced Raman Scattering (SERS) for Cancer Diagnostics

This paper demonstrates a proof-of-concept model using machine learning and SERS to predict cancer from small extracellular vesicles, with explainable AI for interpretability.

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

Insecticidal Effects of Datura Species against Major Agricultural Pests

This study evaluates the insecticidal effects of Datura species against agricultural pests using bioassays with varying concentrations and exposure times.

A conserved ESCRT-II-like protein participates in the biogenesis and maintenance of thylakoid membranes

The paper identifies VIA1, a conserved protein interacting with VIPP1, and shows it is essential for thylakoid membrane biogenesis and maintenance in two photosynthetic organisms.

Plasmodium falciparum Raf kinase inhibitor is a lipid binding protein that interacts with CDPK1 and regulates its activity in asexual blood stage.

This study identifies PfRKIP as a lipid-binding protein in Plasmodium falciparum that interacts with CDPK1, regulates its activity, and its inhibition reduces parasite growth.

Peripheral linker mediates ACP's recognition of DH and stabilizes Mycobacterium tuberculosis FAS-I

The paper identifies key residues and the role of the peripheral linker in stabilizing ACP near DH in Mtb FAS-I using molecular dynamics simulations.

Metagenomic survey of antimicrobial resistance (AMR) in Maryland surface waters differentiated by high and low human impact

The paper surveys antimicrobial resistance in Maryland surface waters, finding higher prevalence of beta-lactamase genes in high human impact areas.

Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

This study identifies DUSP6 as a driver of HER2 inhibitor tolerance through the Neuregulin/HER3 axis by analyzing the transcriptional changes during the DTP-DTEP transition in HER2+ breast cancer cells.

Correlation between antibacterial activity of two Artemisia sp. extracts and their plant characteristics

The paper evaluates antibacterial activity of two Artemisia species extracts and correlates it with plant characteristics using statistical analysis.

Connexin 43 mediated collective cell migration is independent of Golgi orientation

This study shows that Connexin 43 promotes collective cell migration by reducing Golgi reorientation, independent of directed secretory trafficking.

Reservoir Dogs: Consequences of variable contact network structures for disease spread in free-ranging dogs

The paper examines how contact network structures in free-ranging dogs affect rabies spread, finding that village dogs have higher connectivity leading to more disease transmission.

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum

This paper reports the cryo-EM structure and kinetics of sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum, revealing its cofactor usage and catalytic mechanism in sulfolactate synthesis.

Metabolomics reveals nucleoside analogs for regulating mucosal-associated invariant T cell responses

The paper identifies nucleoside analogs from Mycobacterium tuberculosis that regulate MAIT cell activation, revealing conserved ligands across bacterial and mammalian systems.

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

The paper analyzes the relationship between TAD activity and drug response in cancer cells and patients, finding stronger correlations with TADs than individual genes.

The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

SLIT2, a neuro-repellent, enhances neutrophil antibacterial activity against S. aureus by boosting reactive oxygen species production and granule exocytosis, improving infection clearance.

Assembly mechanism of the AIM2 inflammasome sensorrevealed by single-molecule analysis

This study uses single-molecule techniques to reveal how AIM2 forms oligomers on dsDNA, showing distinct nucleation mechanisms and rapid size increase.

mTORC2 couples fasting to mitochondrial fission

The paper shows that mTORC2 activation during fasting promotes mitochondrial fission and respiratory function through NDRG1 phosphorylation and interaction with Cdc42.

RAS and PP2A activities converge on epigenetic gene regulation

This study identifies epigenetic gene regulation as a convergence point for RAS hyperactivity and PP2A inhibition in cancer, showing their co-regulation of key chromatin modifiers and oncogenic transcription.

ORF6 protein of SARS-CoV-2 inhibits TRIM25 mediated RIG-I ubiquitination to mitigate type I IFN induction.

This study identifies ORF6 as a SARS-CoV-2 protein that inhibits TRIM25-mediated RIG-I ubiquitination, thereby blocking type I IFN induction and signaling.

Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models

Mitoquinone mesylate shows antiviral and anti-inflammatory effects against SARS-CoV-2 in preclinical models.

A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models.

This paper identifies picolinic acid as a broad-spectrum antiviral that inhibits enveloped virus entry, showing efficacy against SARS-CoV-2 and Influenza A Virus in animal models.

Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India

The paper reports SARS-CoV-2 infection in a free-ranging Indian leopard, confirming Delta variant infection and highlighting the need for wildlife screening.

Stress response in Entamoeba histolytica is associated with robust processing of tRNA to tRNA-halves

This study identifies tRNA-derived fragments in Entamoeba histolytica, showing their accumulation under stress and during encystation, and their association with Argonaute proteins.

Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis.

This study identifies SLC38A5 as an upregulated amino acid transporter in triple-negative breast cancer that promotes macropinocytosis, expanding its role beyond amino acid transport to support cancer cell nutrition.

Lysosomal Exocytosis Releases Pathogenic α-Synuclein Species from Neurons

The paper identifies lysosomal exocytosis as a mechanism for releasing pathogenic α-synuclein species from neurons.

Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material

The paper shows that Arp2/3 networks induce smooth interfaces between actomyosin networks through mechanosensitive contractility, both in simulations and in vivo.

Nutritional combinatorial impact on the gut microbiota and plasma short-chain fatty acids levels in the prevention of mammary cancer in Her2/neu estrogen receptor-negative transgenic mice

This study evaluates how broccoli sprouts and green tea polyphenols, alone or combined, affect gut microbiota and short-chain fatty acids in mice to prevent estrogen receptor-negative mammary cancer.

Pathway to Validate Gene Function in Key Bioenergy Crop, Sorghum bicolor

The paper develops a method to validate gene function in sorghum by improving transformation efficiency and creating a pathway for high-throughput molecular genotyping.

A negative feedback loop of the TOR signaling moderates growth and enables rapid sensing of stress signals in plants

This study identifies a negative feedback loop involving FLZ8 and SnRK11 that modulates TOR signaling in Arabidopsis, enabling growth regulation and stress response.