Author

A. Aakula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. Westermarck· 2 shared A. Erickson· 1 shared A. Isomursu· 1 shared A. Kaur· 1 shared A. Padzik· 1 shared A. Rannikko· 1 shared C. Arrowsmith· 1 shared C. Rupp· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

J. Westermarck

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Author profile →

2 papers

Recent·Most cited

RAS and PP2A activities converge on epigenetic gene regulation

A. Aakula, M. Sharma, F. Tabaro, H. Honkanen, M. Schapira, C. Arrowsmith, M. Nykter, J. Westermarck

This study identifies epigenetic gene regulation as a convergence point for RAS hyperactivity and PP2A inhibition in cancer, showing their co-regulation of key chromatin modifiers and oncogenic transcription.

bioRxiv · May 11, 2022Cancer Biology

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

A. Aakula, A. Isomursu, C. Rupp, A. Erickson, O. Kauko, P. Shah, A. Padzik, Y. R. Pokharel, A. Kaur, S.-P. Li, L. Trottman, P. Taimen, A. Rannikko, J. Lammerding, I. Paatero, , J. Westermarck

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

bioRxiv · Mar 17, 2022 · PreprintCancer Biology