Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis
I. Nagaretnam, A. Yoneshige, F. Takeuchi, A. Ozaki, M. Tamura, S. Suzuki, T. Shigeoka, A. Ito, Y. Ishida
This study shows that PD-1 knockout mice with genome mutations develop liver granulomatous inflammation, supporting PD-1's role in suppressing autoimmune responses to neoantigens.
bioRxiv · Aug 17, 2023 · PreprintImmunology