A. Ito

Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis

This study shows that PD-1 knockout mice with genome mutations develop liver granulomatous inflammation, supporting PD-1's role in suppressing autoimmune responses to neoantigens.

Evaluation of heat inactivation of human norovirus in freshwater clams using human intestinal enteroids

This study evaluates heat inactivation of human norovirus in freshwater clams using human intestinal enteroids, finding that 1 minute at 90°C inactivates the virus.

Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

The paper identifies neutralizing antibodies from early SARS-CoV-2 infections that retain activity against Omicron and other variants, highlighting the role of germinal center mutations in their broad neutralization.

Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice

This study investigates how Porphyromonas gingivalis LPS affects cardiac function in mice via TLR4 signaling, showing that TLR4 inhibition improves cardiac function.

Serum hormone levels in infertile women between conceived with and without hormone replacement therapy: Safety of estradiol and progesterone replacement therapy in frozen-thawed embryo transfer cycles for breast cancer survivors.

This study compares serum estradiol and progesterone levels in breast cancer survivors who conceived with or without hormone replacement therapy during frozen-thawed embryo transfer cycles, finding no significant increase in hormone levels with HRT.

Repeated inversions at the pannier intron drive diversification of intraspecific colour patterns of ladybird beetles

The paper identifies pannier as a key regulatory gene for color pattern variation in ladybird beetles and shows that inversions and cis-regulatory changes at this gene drive intraspecific diversity.

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2

This study shows that human ASPM and CDK5RAP2 redundantly function in spindle pole organisation during mitosis, with ASPM depletion alone not affecting spindle morphology but causing defects when CDK5RAP2 is also depleted.