Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens
R. Rashu, M. Ninkov, C. M. Wardell, J. M. Benoit, N. I. Wang, M. R. D'Agostino, A. Zhang, E. Feng, N. Saeedian, G. I. Bell, F. Vahedi, D. A. Hess, R. M. Troyer, C. Y. Kang, A. A. Ashkar, , S. M. M. Haeryfar
This study shows that targeting the MR1-MAIT cell axis with 5-OP-RU enhances vaccine efficacy against viral pathogens by expanding and reprogramming MAIT cells.
bioRxiv · Feb 20, 2023Immunology