A. Zhang

Glutamate, GABA, and dense-core vesicle secretion regulate predatory feeding in the nematode Pristionchus pacificus

This study identifies roles for glutamate, GABA, and dense-core vesicle secretion in predatory feeding of P. pacificus using CRISPR/Cas9 mutants.

The effect of circulating neutralizing antibodies on the replication of SARS-CoV-2 variants following post-vaccination infections.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy.

This study investigates the role of the SLO2.1/NALCN complex in regulating mouse myometrial smooth muscle cell membrane potential across pregnancy, finding its activity decreases as pregnancy progresses.

Channel width modulates the permeability of DNA origami based nuclear pore mimics

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming

This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.

WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS

This paper identifies WWP2 as a regulator of myofibroblast metabolic reprogramming in renal fibrosis, showing it suppresses PGC-1 to alter metabolic pathways and reduce fibrosis severity.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

Architecture of the spinach plastid-encoded RNA polymerase

This study presents the cryo-EM structure of the spinach plastid-encoded RNA polymerase complex, revealing its composition and spatial arrangement of subunits and associated proteins.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

Streamlined DNA template preparation and co-transcriptional 5' capped RNA synthesis enabled by solid-phase catalysis

This paper demonstrates a solid-phase enzymatic platform for streamlined mRNA synthesis, enabling efficient and continuous production of capped RNA without purification steps.

Biochemically-functionalized probes for cell type-specific targeting and recording in the brain

This paper develops biochemically-functionalized probes that selectively target and record from specific cell types in the brain, demonstrating their effectiveness in vivo.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

A conserved graft formation process in Picea abies and Arabidopsis thaliana identifies the PAT gene family as central regulators of wound healing

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

Histone variant H2A.Z is required for plant salt response by regulating gene transcription

This study shows H2A.Z regulates plant salt response by modulating gene transcription, with its occupancy affecting gene expression levels under salt stress.

Isolation and nitrogen removal characteristics of a novel aerobic denitrifying strain Achromobacter xylosoxidans GR7397

This study isolates a novel aerobic denitrifying strain, Achromobacter xylosoxidans GR7397, and demonstrates its efficient nitrate removal capacity under optimized conditions.

All-in-one AAV-delivered epigenome-editing platform: proof-of-concept and therapeutic implications for neurodegenerative disorders

This paper develops a compact AAV-delivered dCas9-based repressor system for gene silencing, demonstrating its effectiveness in reducing ApoE expression in vitro and in vivo.

Ultra-flexible endovascular probes for brain recording through micron-scale vasculature

This paper develops ultra-flexible endovascular neural probes for brain recording in small blood vessels without damaging tissue, achieving electrophysiology recordings and long-term stability.

Damage activates EVG1 to suppress vascular differentiation during regeneration in Arabidopsis thaliana

The paper identifies EVG1 as a gene that suppresses vascular differentiation during plant regeneration in response to damage, showing its role in stress responses and interactions with RLP44.

Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens

This study shows that targeting the MR1-MAIT cell axis with 5-OP-RU enhances vaccine efficacy against viral pathogens by expanding and reprogramming MAIT cells.

A maize lipid droplet-associated protein is modulated by a virus to promote viral multiplication and infection

This study shows that rice black streaked dwarf virus recruits a maize lipid droplet-associated protein to regulate fatty acid metabolism, promoting viral multiplication and infection.

Structural insights into ion conduction by novel cation channel, TMEM87A, in Golgi apparatus

This paper presents a high-resolution cryo-EM structure of TMEM87A, revealing its unique architecture and mechanisms of ion conduction and gating in the Golgi apparatus.

In situ genetically targeted chemical assembly of polymers on living neuronal membranes

The paper develops a method to genetically target polymer assembly on neuronal membranes to modify electrical properties with improved efficiency and biocompatibility.

Genetically-encoded photosensitizers enable light-controlled polymerization on living neuronal membranes

This paper introduces a method to control polymerization on living neuronal membranes using light-activated photosensitizers, enabling non-invasive modification of neural circuits.

Study of Pinelliae Rhizoma hepatotoxicity based on complex network algorithm improvement

The paper improves a centrality algorithm by incorporating protein properties and validates it using yeast networks to study the hepatotoxicity of Pinelliae Rhizoma.

A CMOS-based highly scalable flexible neural electrode interface

This paper develops a scalable flexible neural interface to connect high-density electrode arrays to silicon chips, demonstrating its effectiveness in measuring neural activity in a mouse model.

Extreme diversity of mycoviruses present in four strains of Rhizoctonia cerealis, the pathogen of wheat sharp eyespot

The paper analyzes viral genomes from four strains of Rhizoctonia cerealis, identifying 131 novel or unclassified mycoviruses and proposing new taxonomic classifications.