Cancer BiologybioRxiv
Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia
R. Tirtakusuma, K. Szoltysek, P. Milne…·M. J Thirman
This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.
DOI 10.1182/blood.2021015036