Author

C. Eckert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. Schrappe· 2 shared A. Akalin· 1 shared A. E. Kulozik· 1 shared A. Elder· 1 shared A. Hren· 1 shared A. Komkov· 1 shared A. Mathioudaki· 1 shared A. Ptasinska· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

M. Schrappe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Role of Stem-Like Cells in Chemotherapy Resistance and Relapse in pediatric T Cell Acute Lymphoblastic Leukemia

J. Costea, K. K. Rauwolf, P. Zafferani, T. Rausch, A. Mathioudaki, J. B. Zaugg, M. Schrappe, C. Eckert, G. Escherich, J.-P. Bourquin, B. Bornhauser, A. E. Kulozik, J. O. Korbel

This study identifies treatment-resistant stem-like T-ALL cells that expand during relapse using single-cell RNA sequencing of pediatric T-ALL patient samples.

bioRxiv · Jun 24, 2024Cancer Biology

High-density CRISPRi screens reveal adaptive transcriptional gradients in cyanobacteria

A. Hren, N. Lollini, D. L. Carper, P. E. Abraham, J. C. Cameron, J. M. Fox, C. Eckert

This study uses CRISPRi screens to identify transcriptional gradients in Synechococcus sp. PCC 7002 that improve growth under cold monochromatic light conditions.

bioRxiv · May 20, 2024 · PreprintMicrobiology

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.

S. Le Blanc, N. Ishaque, J. Jabs, T. Bauer, S. Schuth, Q. Hu, O. Debnath, F. W. Ten, C.-S. Leonhardt, A.-K. König, M. Bieg, C. Eckert, M. M. Gaida, M. Volkmar, D. Hübschmann, , O. Strobel

This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.

bioRxiv · Aug 26, 2021 · PreprintCancer Biology

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

R. Tirtakusuma, K. Szoltysek, P. Milne, V. V. Grinev, A. Ptasinska, C. Meyer, S. Nakjang, J. Y. Hehir-Kwa, D. Williamson, P. Cauchy, S. A. Assi, M. R. Imperato, F. Vogiatzi, S. Lin, M. Wunderlich, , M. J Thirman

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

bioRxiv · Jul 16, 2021Cancer Biology

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

A. Rani James, M. P. Schroeder, M. Neumann, L. Bastian, C. Eckert, N. Gökbuget, J. O. Tanchez, C. Schlee, K. Isaakidis, S. Schwartz, T. Burmeister, A. v. Stackelberg, M. A. Rieger, S. Göllner, M. Horstman, , C. D. Baldus

This study identifies subtype and relapse-specific long non-coding RNAs in B cell precursor acute lymphoblastic leukemia and links them to molecular pathways and epigenetic regulation.

bioRxiv · Jul 9, 2018Cancer Biology