C. Meyer

Histidine limitation causes alteration in the TOR network and plant development

The paper shows that reduced histidine levels in the sune82 mutant alter the TOR network and affect plant development.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

The interacting effects of climate and land-use/land-cover changes on ecological communities

The paper examines how climate and land-use/land-cover changes interact to affect bird communities in the U.S., finding complex effects on species richness and abundance.

Modelling the probability of meeting IUCN Red List criteria to support reassessments.

This paper develops models to predict the probability of species meeting specific IUCN Red List criteria, improving extinction risk assessments by identifying key predictors for each criterion.

Post-translational regulation of photosynthetic activity via the TOR kinase in plants.

The paper identifies a TOR-RSH3 signaling axis that post-translationally regulates photosynthetic activity in plants by controlling ppGpp signaling.

Proteomic analyses of the Arabidopsis cap-binding complex define core set and TOR-dependent protein components

The paper identifies core and TOR-dependent components of the Arabidopsis cap-binding complex through proteomic analyses under various conditions affecting translation.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

The Arabidopsis Target of Rapamycin (TOR) kinase regulates ammonium assimilation and glutamine metabolism

The study shows that inhibiting the TOR kinase in Arabidopsis affects ammonium uptake and causes glutamine accumulation dependent on glutamine synthetase activity.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

The paper shows that mouse and human kidneys produce biologically active vasopressin in response to NaCl-induced hypertonicity and water restriction.

The grape MYB24 mediates the coordination of light-induced terpene and flavonol accumulation in response to berry anthocyanin sunscreen depletion

The paper identifies MYB24 as a transcription factor coordinating light-induced terpene and flavonol accumulation in response to anthocyanin depletion in grape berries.

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

Policy-relevant indicators for invasive alien species assessment and reporting

The paper introduces three policy-relevant indicators for assessing invasive alien species, focusing on spread rates, impact risk, and status information.

Peer teaching as bioinformatics training strategy: incentives, challenges, and benefits.

This study evaluates peer teaching workshops as a bioinformatics training strategy, identifying benefits like improved communication skills and challenges like time constraints and classroom management.

Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway

This study shows heat-inactivated MVA enhances Th1 immune responses by activating the STING pathway and improves antitumor efficacy when combined with antigens.

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

Are indigenous territories effective natural climate solutions? A neotropical analysis using matching methods and geographic discontinuity designs.

This study evaluates the effectiveness of Indigenous Territories as natural climate solutions in the Neotropics using matching methods and geographic discontinuity designs, finding they preserve carbon stocks and buffer losses similarly to Protected Areas.

Global and national trends in documenting and monitoring species distributions

The paper analyzes global and national trends in documenting species distributions from 1950-2019, finding increasing data coverage but persistent geographic and taxonomic biases.

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

A cross-scale assessment of productivity-diversity relationships

This study examines how productivity influences diversity (NPP→S) and diversity influences productivity (S→NPP) across different spatial scales in North American forests.

A review of models of natural pest control: toward predictions across agricultural landscapes

This paper reviews models of natural pest control and identifies their strengths and limitations in predicting pest dynamics across agricultural landscapes.

Kin structure and roost fidelity in greater noctule bats

The paper examines roost fidelity in greater noctule bats, finding that relatedness, not genetic distance, influences group-sharing behavior.

A clinically and genomically annotated nerve sheath tumor biospecimen repository.

The paper establishes a clinically and genomically annotated nerve sheath tumor biospecimen repository to support research on NF1-related tumors.

Differences in berry primary and secondary metabolisms identified by transcriptomic and metabolic profiling of two table grape color somatic variants

The paper compares transcriptomic and metabolic profiles of two table grape cultivars with different berry skin colors, identifying differences in flavonoid and primary metabolite composition and gene expression.

Growing old too early, automated assessment of skeletal muscle single fiber biomechanics in ageing R349P desmin knock-in mice using the MyoRobot technology

This study assesses skeletal muscle biomechanics in R349P desmin knock-in mice using MyoRobot technology, finding increased axial stiffness and accelerated shortening in mutant fibers compared to wild-type.

A DNA barcode reference library of the French Polynesian shore fishes

This paper presents a DNA barcode reference library for 2,190 shore fish specimens from French Polynesia, covering 540 species and providing a comprehensive resource for biodiversity studies.

Direct monitoring of cAMP at the cardiac ryanodine receptor using a novel targeted fluorescence biosensor mouse

The paper develops a targeted fluorescence biosensor in transgenic mice to monitor cAMP levels near RyR2 in cardiomyocytes, revealing altered cAMP dynamics in cardiac hypertrophy.

Renewal theory provides a universal quantitative framework to characterise the continuous regeneration of rotational events in cardiac fibrillation

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.