Fan Jiang

MAXWELL: Calibrating the probabilistic outputs of protein language models to the mutation-induced stability change landscape

MAXWELL calibrates protein language models to predict mutation-induced stability changes, outperforming existing methods and successfully designing stabilizing mutations in DhaA dehalogenase.

Revealing a Correlation between Structure and in vitro Activity of mRNA Lipid Nanoparticles

This study investigates the structure-activity relationship of mRNA-LNPs, finding that a more ordered internal structure correlates with higher in vitro activity.

Simple Methods to Acutely Measure Multiple Timing Metrics among Sexual Repertoire of Male Drosophila

This paper introduces an automated system to measure multiple timing metrics in Drosophila courtship behavior with high accuracy and minimal manual effort.

How to select the best zero-shot model for the viral proteins?

This paper introduces ProPEC, a perplexity-based ensemble model for zero-shot prediction of viral protein fitness, showing improved performance over individual models.

Quantitative Control of Noise in Mammalian Gene Expression by Dynamic Histone Regulations

This study investigates how dynamic histone regulations control noise in gene expression by showing that a positive feedback loop between transcriptional activators and histone acetyltransferases generates epigenetic bistability, leading to large noise, which can be reduced by modulating activator binding.