Molecular BiologyeLifePeer-reviewed
Quantitative Control of Noise in Mammalian Gene Expression by Dynamic Histone Regulations
Deng Tan, Rui Chen, Yuejian Mo…·Wei Huang
This study investigates how dynamic histone regulations control noise in gene expression by showing that a positive feedback loop between transcriptional activators and histone acetyltransferases generates epigenetic bistability, leading to large noise, which can be reduced by modulating activator binding.